Sir2 like Proteins
《英文msh詞典》Sir2 like Proteins
[入口詞] Sir2 like Proteins
[主題詞] Sirtuins
[英文釋義] A homologous family of proteins that includes the NAD-dependent protein deacetylases which deacetylate proteins by catalyzing the formation of O-acetyl-ADP-ribose from the ADP-RIBOSE moiety (of NAD) and the acetyl group that is being removed from the protein. Sir2p,from Saccharomyces cerevisiae,is the founding member and the family includes other homologs (HSTs - homologs of Sir Two). Some HISTONE DEACETYLASES (the Sir2-like HDACs) belong to this family of proteins.